The game takes place in a dystopian future where mankind has exhausted the world's resources, leading to strained social service and environmental diseases. According to the developers, the game paints a grim portrait of the future where the evolution of technology in relation to society and the environment has led to a decadent era for humanity. The proliferation of drones and working robots has created mass unemployment, with humans forced to resort to augmentations and powered rigs to keep up with a far more efficient equivalent.

The player takes control of Warren, a new employee on his first day on the job on board a bullet train towards the headquarters of CREO, one of the largest tech conglomerates now controlling the world, renowned for its revolutionary breakthroughs in a multitude of fields, from common household items to advanced exoskeletons. Its most relevant activity however is "Project reSOLVE", ideated by its founder Jonah Guttenberg, which involves a complex chemical formula dispersed via rockets to slowly reseed the Earth's damaged atmosphere, as well as boost the growth of flora worldwide.

After choosing a starting robotic rig, Warren (who uses a wheelchair) is prepared for surgical implantation of an advanced CREO exoskeleton, gone horribly wrong when the automated system fails to sedate him, painfully grafting each component until he passes out during neurosurgery. Waking up, Warren finds the facility in ruins, with drones attacking personnel and fellow workers prey to a deranged bloodthirst. Guided by an executive known only as "Sally", Warren is forced to traverse the entire complex, up to the Executive Forum, in order to find out what exactly happened.