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$\beta$-Nicotinamide Mononucleotide, commonly known as NMN, is a naturally occurring nucleotide and a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme found in every cell of the human body.1 As people age, systemic levels of NAD+ decline significantly, contributing to metabolic dysfunction, DNA damage, and age-related physiological decline.2 Supplementing with NMN is primarily aimed at restoring these levels, as the molecule is rapidly absorbed and converted into NAD+ within tissues.3 By boosting NAD+, NMN supports the activation of sirtuins—a family of "longevity proteins" that regulate cellular health, repair damaged DNA, and maintain mitochondrial efficiency.4 While much of the early evidence for NMN’s life-extending and metabolic benefits comes from animal models, recent human clinical trials have shown promising results in improving insulin sensitivity, enhancing aerobic capacity in athletes, and reducing markers of arterial stiffness
Restores NAD+ Levels: Acts as a direct precursor to replenish Nicotinamide Adenine Dinucleotide (NAD+), which naturally declines by about 50% by the time we reach middle age.
Activates "Longevity Genes": Supplies the NAD+ necessary to trigger sirtuins (specifically SIRT1), proteins that regulate cellular aging, stress resistance, and DNA protection.
Boosts Mitochondrial Energy: Enhances the function of mitochondria (the cell's power plants), leading to increased production of ATP and improved physical stamina.
Facilitates DNA Repair: Powers enzymes like PARP, which are responsible for identifying and fixing damage to our genetic code caused by UV light and environmental toxins.
Improves Insulin Sensitivity: Clinical studies have shown that NMN can improve the way muscles process glucose, helping to maintain healthy blood sugar levels and metabolic health.
Enhances Cognitive Function: Supports neurovascular health and blood flow to the brain, which may improve memory, focus, and protect against age-related cognitive decline.
Promotes Vascular Health: Helps reverse the "stiffening" of blood vessels and improves capillary density, supporting overall cardiovascular endurance and heart health.
Supports Muscle Strength: Human trials on older adults have indicated that NMN can lead to measurable improvements in grip strength and walking speed.
Protects Eye Health: Helps maintain healthy retinal function and may prevent the decline in vision often associated with aging and oxidative stress.
Regulates Circadian Rhythms: By boosting NAD+, NMN helps "reset" the body’s internal clock, which can improve sleep quality and metabolic timing.
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