Resistance: Fall of Man is a 2006 science-fiction first-person shooter video game for the PlayStation 3. It was developed by Insomniac Games and published by Sony Computer Entertainment. The game is set in an alternate history 1951, and follows Sergeant Nathan Hale as he and the human resistance forces attempt to drive a mysterious alien-like invasion out of the United Kingdom. The story continues in Resistance 2.

The game was originally developed under the title I-8, as it was the eighth title to be in production by Insomniac Games. It was released as a PlayStation 3 launch title in the United States on November 17, 2006 and in the PAL region on March 23, 2007. Resistance had positive critical reception, garnering particular praise in view of its status as a launch title and winning several awards. As of 2007, the game sold more than 2.1 million copies.

Sony and Insomniac Games became embattled with the Church of England for using interior shots of Manchester Cathedral to recreate the building within the game, as well as "promoting violence" within the building.