Guitar Hero: Warriors of Rock (initially referred to as Guitar Hero 6 or Guitar Hero VI) is a 2010 music rhythm video game developed by Neversoft and published by Activision. It is the sixth main installment in the Guitar Hero series. The game was released in September 2010 for PlayStation 3, Wii, and Xbox 360. Similar to previous entries in the franchise, it is geared towards playing in a four-person band experience, including lead and bass guitar, drums, and vocals. The game is available as a standalone title, allowing players to use existing compatible instrument controllers, and as a bundle that provides these controllers.

Warriors of Rock shares core gameplay elements with its predecessors, but introduced a new story mode in which the player must recruit eight characters—each with a unique ability that modifies the mechanics of the game—to help defeat an antagonist known as "The Beast".The storyline also incorporated Rush's seven-part "2112", as well as "Sudden Death", a new song performed by Megadeth to serve as its culmination (the song would later be included in Megadeth's following album, TH1RT3EN). Warriors of Rock carried over core gameplay and multiplayer functionality introduced by Guitar Hero 5, including per-song bonus challenges, and the ability to use power-ups from the story mode in standard gameplay.