Madden NFL 06 is an American football video game which was released in 2005. It is also a launch game for the Xbox 360. It is the 16th installment of the Madden NFL series by EA Sports, named for noted color commentator John Madden. The product features former Philadelphia Eagles quarterback Donovan McNabb on the cover. It is the first Madden game for the PlayStation Portable and Xbox 360.

The game's box art was the first Madden football game to not include Madden's picture on it. The game also features WWE and UFC superstar, Brock Lesnar as a playable character for the Minnesota Vikings.Madden 06 introduces the Superstar mode, which allows the player to create and take control of an NFL player from his rookie year all the way to retirement. An athlete can be created by evaluating pairs of judging, based on their IQs, occupations, and hobbies, whether their child would excel in the NFL or by importing a player. Superstar mode is essentially Madden's Franchise mode seen through the eyes of this athlete. Rather than manage the team's front office, the player manages the career of his athlete.